The best thing about Duane Reade is that they are open 24 hours. This makes it convenient when you realize you are totally out of cat food at 11:45pm and Mr. Orange isn't happy since he hasn't eaten since lunch time.
But what really sucks is when you belong to their Dollar Rewards Club and then you forget to use the $5 coupon before it expires. I hate the way you can't use it at the same time that they issue the coupon. They give you two weeks to use it, but I forget to use it more often than I would like. I'm sure they totally count on this happening.